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DNA conformational changes at the primer-template junction regulate the fidelity of replication by DNA polymerase

Local conformational changes in primer-template (P/T) DNA are involved in the selective incorporation of dNTP by DNA polymerases (DNAP). Here we use near UV CD and fluorescence spectra of pairs of base analogue probes, substituted either at the primer terminus or in the coding region of the template...

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Bibliografiske detaljer
Main Authors: Datta, Kausiki, Johnson, Neil P., von Hippel, Peter H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964193/
https://ncbi.nlm.nih.gov/pubmed/20921373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012277107
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