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DNA conformational changes at the primer-template junction regulate the fidelity of replication by DNA polymerase
Local conformational changes in primer-template (P/T) DNA are involved in the selective incorporation of dNTP by DNA polymerases (DNAP). Here we use near UV CD and fluorescence spectra of pairs of base analogue probes, substituted either at the primer terminus or in the coding region of the template...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964193/ https://ncbi.nlm.nih.gov/pubmed/20921373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012277107 |
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