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Local Conformations and Competitive Binding Affinities of Single- and Double-stranded Primer-Template DNA at the Polymerization and Editing Active Sites of DNA Polymerases

In addition to their capacity for template-directed 5′ → 3′ DNA synthesis at the polymerase (pol) site, DNA polymerases have a separate 3′ → 5′ exonuclease (exo) editing activity that is involved in assuring the fidelity of DNA replication. Upon misincorporation of an incorrect nucleotide residue, t...

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Detalhes bibliográficos
Main Authors: Datta, Kausiki, Johnson, Neil P., LiCata, Vince J., von Hippel, Peter H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719356/
https://ncbi.nlm.nih.gov/pubmed/19411253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007641
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