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Exploring the role of large conformational changes in the fidelity of DNA polymerase β
The relationships between the conformational landscape, nucleotide insertion catalysis and fidelity of DNA polymerase β are explored by means of computational simulations. The simulations indicate that the transition states for incorporation of right (R) and wrong (W) nucleotides reside in substanti...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2365506/ https://ncbi.nlm.nih.gov/pubmed/17671961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.21668 |
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