Exploring the role of large conformational changes in the fidelity of DNA polymerase β

The relationships between the conformational landscape, nucleotide insertion catalysis and fidelity of DNA polymerase β are explored by means of computational simulations. The simulations indicate that the transition states for incorporation of right (R) and wrong (W) nucleotides reside in substanti...

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Bibliographic Details
Main Authors: Xiang, Yun, Goodman, Myron F., Beard, William A., Wilson, Samuel H., Warshel, Arieh
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365506/
https://ncbi.nlm.nih.gov/pubmed/17671961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.21668
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