Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

Although the linkage of Chk1 and Chk2 to important cancer signalling suggests that these kinases have functions as tumour suppressors, neither Chk1(+/−) nor Chk2(−/−) mice show a predisposition to cancer under unperturbed conditions. We show here that Chk1(+/−)Chk2(−/−) and Chk1(+/−)Chk2(+/−) mice h...

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Main Authors: Niida, Hiroyuki, Murata, Kazuhiro, Shimada, Midori, Ogawa, Kumiko, Ohta, Kumiko, Suzuki, Kyoko, Fujigaki, Hidetsugu, Khaw, Aik Kia, Banerjee, Birendranath, Hande, M Prakash, Miyamoto, Tomomi, Miyoshi, Ichiro, Shirai, Tomoyuki, Motoyama, Noboru, Delhase, Mireille, Appella, Ettore, Nakanishi, Makoto
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964167/
https://ncbi.nlm.nih.gov/pubmed/20834228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.218
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