Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling

The tumour suppressor gene product Mig-6 acts as an inhibitor of epidermal growth factor (EGF) signalling. However, its posttranslational modifications and regulatory mechanisms have not been elucidated. Here, we investigated the phosphorylation of human Mig-6 and found that Chk1 phosphorylated Mig-...

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Detalhes bibliográficos
Main Authors: Liu, Ning, Matsumoto, Masaki, Kitagawa, Kyoko, Kotake, Yojiro, Suzuki, Sayuri, Shirasawa, Senji, Nakayama, Keiichi I, Nakanishi, Makoto, Niida, Hiroyuki, Kitagawa, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364749/
https://ncbi.nlm.nih.gov/pubmed/22505024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.88
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