Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

Although the linkage of Chk1 and Chk2 to important cancer signalling suggests that these kinases have functions as tumour suppressors, neither Chk1(+/−) nor Chk2(−/−) mice show a predisposition to cancer under unperturbed conditions. We show here that Chk1(+/−)Chk2(−/−) and Chk1(+/−)Chk2(+/−) mice h...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Niida, Hiroyuki, Murata, Kazuhiro, Shimada, Midori, Ogawa, Kumiko, Ohta, Kumiko, Suzuki, Kyoko, Fujigaki, Hidetsugu, Khaw, Aik Kia, Banerjee, Birendranath, Hande, M Prakash, Miyamoto, Tomomi, Miyoshi, Ichiro, Shirai, Tomoyuki, Motoyama, Noboru, Delhase, Mireille, Appella, Ettore, Nakanishi, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964167/
https://ncbi.nlm.nih.gov/pubmed/20834228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.218
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados