Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

The mammalian Chk2 kinase is thought to mediate ATM-dependent signaling in response to DNA damage. The physiological role of mammalian Chk2 has now been investigated by the generation of Chk2-deficient mice. Although Chk2(–/–) mice appeared normal, they were resistant to ionizing radiation (IR) as a...

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Detalhes bibliográficos
Main Authors: Takai, Hiroyuki, Naka, Kazuhito, Okada, Yuki, Watanabe, Miho, Harada, Naoki, Saito, Shin’ichi, Anderson, Carl W., Appella, Ettore, Nakanishi, Makoto, Suzuki, Hiroshi, Nagashima, Kazuo, Sawa, Hirofumi, Ikeda, Kyoji, Motoyama, Noboru
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129029/
https://ncbi.nlm.nih.gov/pubmed/12356735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf506
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