Hypoxia-induced in vivo sickling of transgenic mouse red cells.

To develop an animal model for sickle cell anemia, we have created transgenic mice that express a severe naturally occurring human sickling hemoglobin, Hb S Antilles. Due to its low solubility and oxygen affinity, Hb S Antilles has a greater propensity to cause red cell sickling than Hb S. To make t...

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Bibliografiske detaljer
Main Authors: Rubin, E M, Witkowska, H E, Spangler, E, Curtin, P, Lubin, B H, Mohandas, N, Clift, S M
Format: Artigo
Sprog:Inglês
Udgivet: 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC296354/
https://ncbi.nlm.nih.gov/pubmed/1991848
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