Hypoxia-induced in vivo sickling of transgenic mouse red cells.

To develop an animal model for sickle cell anemia, we have created transgenic mice that express a severe naturally occurring human sickling hemoglobin, Hb S Antilles. Due to its low solubility and oxygen affinity, Hb S Antilles has a greater propensity to cause red cell sickling than Hb S. To make t...

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Pubblicato in:	J Clin Invest
Autori principali:	Rubin, E M, Witkowska, H E, Spangler, E, Curtin, P, Lubin, B H, Mohandas, N, Clift, S M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1991848/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115041
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