Hypoxia-induced in vivo sickling of transgenic mouse red cells.
To develop an animal model for sickle cell anemia, we have created transgenic mice that express a severe naturally occurring human sickling hemoglobin, Hb S Antilles. Due to its low solubility and oxygen affinity, Hb S Antilles has a greater propensity to cause red cell sickling than Hb S. To make t...
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| Published in: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1991
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1991848/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115041 |
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