INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells

OBJECTIVE: In diabetes, β-cell mass is not static but in a constant process of cell death and renewal. Inactivating mutations in transcription factor 1 (tcf-1)/hepatocyte nuclear factor1a (hnf1a) result in decreased β-cell mass and HNF1A–maturity onset diabetes of the young (HNF1A-MODY). Here, we in...

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Autores principales: Bonner, Caroline, Bacon, Siobhán, Concannon, Caoimhín G., Rizvi, Syed R., Baquié, Mathurin, Farrelly, Angela M., Kilbride, Seán M., Dussmann, Heiko, Ward, Manus W., Boulanger, Chantal M., Wollheim, Claes B., Graf, Rolf, Byrne, Maria M., Prehn, Jochen H.M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963538/
https://ncbi.nlm.nih.gov/pubmed/20682686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1478
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