Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

BACKGROUND: Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result in the commonest type of maturity onset diabetes of the young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate of apoptosis. To date, it has not be...

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Autors principals: Bacon, Siobhan, Kyithar, Ma Peyh, Schmid, Jasmin, Rizvi, Syed R, Bonner, Caroline, Graf, Rolf, Prehn, Jochen HM, Byrne, Maria M
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433346/
https://ncbi.nlm.nih.gov/pubmed/22808921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6823-12-13
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