ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”

In response to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, three ER transmembrane signaling proteins, inositol-requiring enzyme 1 (IRE1), PRKR-like ER kinase (PERK), and activating transcription factor 6α (ATF6α), are activated. These proteins initiate a signaling a...

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Foilsithe in:J Biol Chem
Main Authors: Walter, Franziska, O'Brien, Aisling, Concannon, Caoimhín G., Düssmann, Heiko, Prehn, Jochen H. M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254332/
https://ncbi.nlm.nih.gov/pubmed/30287689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002121
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