Bone Morphogenetic Protein 3 Controls Insulin Gene Expression and Is Down-regulated in INS-1 Cells Inducibly Expressing a Hepatocyte Nuclear Factor 1A–Maturity-onset Diabetes of the Young Mutation

Inactivating mutations in the transcription factor hepatocyte nuclear factor (HNF) 1A cause HNF1A–maturity-onset diabetes of the young (HNF1A-MODY), the most common monogenic form of diabetes. To examine HNF1A-MODY-induced defects in gene expression, we performed a microarray analysis of the transcr...

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Bibliographic Details
Main Authors: Bonner, Caroline, Farrelly, Angela M., Concannon, Caoimhín G., Dussmann, Heiko, Baquié, Mathurin, Virard, Isabelle, Wobser, Hella, Kögel, Donat, Wollheim, Claes B., Rupnik, Marjan, Byrne, Maria M., König, Hans-Georg, Prehn, Jochen H. M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138325/
https://ncbi.nlm.nih.gov/pubmed/21628466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215525
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