2E8 Binds to the High Affinity I-domain in a Metal Ion-dependent Manner: A SECOND GENERATION MONOCLONAL ANTIBODY SELECTIVELY TARGETING ACTIVATED LFA-1

The activation of leukocyte function-associated antigen-1 (LFA-1) plays a critical role in regulating immune responses. The metal ion-dependent adhesion site on the I-domain of LFA-1 α(L) subunit is the key recognition site for ligand binding. Upon activation, conformation changes in the I-domain ca...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Carreño, Roberto, Brown, Wells S., Li, Dan, Hernandez, Jessica A., Wang, Yang, Kim, Tae Kon, Craft, John W., Komanduri, Krishna V., Radvanyi, Laszlo G., Hwu, Patrick, Molldrem, Jeffrey J., Legge, Glen B., McIntyre, Bradley W., Ma, Qing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2010
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963386/
https://ncbi.nlm.nih.gov/pubmed/20724473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111591
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