Blocking LFA-1 Activation with Lovastatin Prevents Graft-versus-Host Disease in Mouse Bone Marrow Transplantation

Graft-versus-host disease (GVHD) following bone marrow transplantation (BMT) is mediated by alloreactive donor T lymphocytes. Migration and activation of donor-derived T lymphocytes play critical roles in the development of GVHD. Leukocyte function associated antigen-1 (LFA-1) regulates T cell adhes...

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Publicado no:Biol Blood Marrow Transplant
Main Authors: Wang, Yang, Li, Dan, Jones, Dan, Bassett, Roland, Sale, George E., Khalili, Jahan, Komanduri, Krishna V., Couriel, Daniel R., Champlin, Richard E., Molldrem, Jeffrey J., Ma, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809421/
https://ncbi.nlm.nih.gov/pubmed/19896074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2009.08.013
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