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Mechanism of E1-E2 Interaction for the Inhibition of Ubl Adenylation
Conjugates of ubiquitin or its homologues to other proteins occur by strictly ordered steps with ordered addition of substrates for each step. High concentrations of E2 were shown to inhibit the formation of E2∼Ubl thioester and Ubl∼target conjugates. We investigated the mechanism of such inhibitory...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963334/ https://ncbi.nlm.nih.gov/pubmed/20682785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135582 |
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