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Mechanism of E1-E2 Interaction for the Inhibition of Ubl Adenylation

Conjugates of ubiquitin or its homologues to other proteins occur by strictly ordered steps with ordered addition of substrates for each step. High concentrations of E2 were shown to inhibit the formation of E2∼Ubl thioester and Ubl∼target conjugates. We investigated the mechanism of such inhibitory...

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Détails bibliographiques
Auteurs principaux: Wang, Jianghai, Cai, Sheng, Chen, Yuan
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963334/
https://ncbi.nlm.nih.gov/pubmed/20682785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135582
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