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Small Ubiquitin-like Modifier (SUMO) Modification of E1 Cys Domain Inhibits E1 Cys Domain Enzymatic Activity

Although it is well established that ubiquitin-like modifications are tightly regulated, it has been unclear how their E1 activities are controlled. In this study, we found that the SAE2 subunit of the small ubiquitin-like modifier (SUMO) E1 is autoSUMOylated at residue Lys-236, and SUMOylation was...

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Detalhes bibliográficos
Main Authors: Truong, Khue, Lee, Terry D., Chen, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346124/
https://ncbi.nlm.nih.gov/pubmed/22403398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353789
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