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Design of High-Activity Mutants of Human Butyrylcholinesterase against (−)-Cocaine: Structural and Energetic Factors Affecting the Catalytic Efficiency
The present study was aimed to explore the correlation between the protein structure and catalytic efficiency of butyrylcholinesterase (BChE) mutants against (−)-cocaine by modeling the rate-determining transition state (TS1), i.e. the transition state for the first step of chemical reaction process...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963158/ https://ncbi.nlm.nih.gov/pubmed/20886866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1011628 |
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