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β-Secretase as a therapeutic target for Alzheimer’s disease
β-Secretase (memapsin 2, BACE1) is an attractive target for the development of inhibitor drugs to treat Alzheimer’s disease (AD). Not only does this protease function at the first step in the pathway leading to the production of amyloid-β (Aβ), its gene deletion produces only mild phenotypes. In add...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963069/ https://ncbi.nlm.nih.gov/pubmed/18625451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nurt.2008.05.007 |
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