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β-Secretase as a therapeutic target for Alzheimer’s disease

β-Secretase (memapsin 2, BACE1) is an attractive target for the development of inhibitor drugs to treat Alzheimer’s disease (AD). Not only does this protease function at the first step in the pathway leading to the production of amyloid-β (Aβ), its gene deletion produces only mild phenotypes. In add...

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Bibliographic Details
Main Authors: Ghosh, Arun K., Gemma, Sandra, Tang, Jordan
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963069/
https://ncbi.nlm.nih.gov/pubmed/18625451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nurt.2008.05.007
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