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Developing β-secretase inhibitors for treatment of Alzheimer’s disease
β-Secretase (memapsin 2; BACE1) is the first protease in the processing of amyloid precursor protein leading to the production of amyloid-β (Aβ) in the brain. It is believed that high levels of brain Aβ are responsible for the pathogenisis of Alzheimer’s disease (AD). Therefore, β-secretase is a maj...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276244/ https://ncbi.nlm.nih.gov/pubmed/22122681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07476.x |
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