Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA

BACKGROUND AND PURPOSE: Long-term morphine treatment enhances pain neurotransmitter [such as calcitonin gene-related peptide (CGRP)] levels in the spinal cord. It has been suggested previously that increased spinal CGRP may contribute to sustained morphine-mediated paradoxical pain sensitization and...

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Autores principales: Tumati, S, Roeske, WR, Largent-Milnes, T, Wang, R, Vanderah, TW, Varga, EV
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2010
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962816/
https://ncbi.nlm.nih.gov/pubmed/20718739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00869.x
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