Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine Kras(G12D)-Induced Skin Carcinogenesis In Vivo

BACKGROUND: The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor cell population, Pdx1-Cre mice were utilize...

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Detalhes bibliográficos
Main Authors: Mazur, Pawel K., Grüner, Barbara M., Nakhai, Hassan, Sipos, Bence, Zimber-Strobl, Ursula, Strobl, Lothar J., Radtke, Freddy, Schmid, Roland M., Siveke, Jens T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962652/
https://ncbi.nlm.nih.gov/pubmed/21042537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013578
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