Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

Late-onset and sporadic Alzheimer's disease are associated with the apolipoprotein E (apoE) type 4 allele expressing the protein isoform apoE4. Apolipoprotein E binds avidly to beta amyloid (A beta) peptide, a major component of senile plaque of Alzheimer's disease, in an isoform-specific...

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Main Authors: Sanan, D A, Weisgraber, K H, Russell, S J, Mahley, R W, Huang, D, Saunders, A, Schmechel, D, Wisniewski, T, Frangione, B, Roses, A D
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC296168/
https://ncbi.nlm.nih.gov/pubmed/8040342
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