Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

Apolipoprotein (apo) E4 is a major risk factor for Alzheimer's disease, and many studies have suggested that apoE has isoform-specific effects on the deposition or clearance of amyloid β (Aβ) peptides. We examined the effects of apoE isoforms on the processing of amyloid precursor protein (APP)...

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Bibliografski detalji
Glavni autori: Ye, Shiming, Huang, Yadong, Müllendorff, Karin, Dong, Liming, Giedt, Gretchen, Meng, Elaine C., Cohen, Fred E., Kuntz, Irwin D., Weisgraber, Karl H., Mahley, Robert W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1311738/
https://ncbi.nlm.nih.gov/pubmed/16344478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508693102
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