Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

The apolipoprotein E (apoE) type 4 allele (APOE4) is a susceptibility gene for late-onset familial and sporadic Alzheimer disease. ApoE is found in some neurofibrillary tangle-bearing neurons, one of the major pathologic hallmarks of the disease. Neurofibrillary tangles contain paired helical filame...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Strittmatter, W J, Saunders, A M, Goedert, M, Weisgraber, K H, Dong, L M, Jakes, R, Huang, D Y, Pericak-Vance, M, Schmechel, D, Roses, A D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45191/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972031/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.11183
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