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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque) with high avidity. Amino acids...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Strittmatter, W J, Saunders, A M, Schmechel, D, Pericak-Vance, M, Enghild, J, Salvesen, G S, Roses, A D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46003/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8446617/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.5.1977
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