Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary tangles of Alzheimer disease. Late-onset familial and sporadic Alzheimer disease patients have an increased frequency...

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Main Authors: Strittmatter, W J, Weisgraber, K H, Huang, D Y, Dong, L M, Salvesen, G S, Pericak-Vance, M, Schmechel, D, Saunders, A M, Goldgaber, D, Roses, A D
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC47295/
https://ncbi.nlm.nih.gov/pubmed/8367470
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