Alkylation of the Tumor Suppressor PTEN Activates Akt and β-Catenin Signaling: A Mechanism Linking Inflammation and Oxidative Stress with Cancer

PTEN, a phosphoinositide-3-phosphatase, serves dual roles as a tumor suppressor and regulator of cellular anabolic/catabolic metabolism. Adaptation of a redox-sensitive cysteinyl thiol in PTEN for signal transduction by hydrogen peroxide may have superimposed a vulnerability to other mediators of ox...

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Autors principals: Covey, Tracy M., Edes, Kornelia, Coombs, Gary S., Virshup, David M., Fitzpatrick, Frank A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958828/
https://ncbi.nlm.nih.gov/pubmed/20975834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013545
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