Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

Recent evidence suggests that many malignancies, including breast cancer, are driven by a cellular subcomponent that displays stem cell-like properties. The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor pro...

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Autors principals: Korkaya, Hasan, Paulson, Amanda, Charafe-Jauffret, Emmanuelle, Ginestier, Christophe, Brown, Marty, Dutcher, Julie, Clouthier, Shawn G., Wicha, Max S.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683567/
https://ncbi.nlm.nih.gov/pubmed/19492080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000121
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