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Targeting HER2: A report on the in vitro and in vivo pre-clinical data supporting trastuzumab as a radioimmunoconjugate for clinical trials

The potential of the HER2-targeting antibody trastuzumab as a radioimmunoconjugate useful for both imaging and therapy was investigated. Conjugation of trastuzumab with the acyclic bifunctional chelator CHX-A″-DTPA yielded a chelate:protein ratio of 3.4 ± 0.3; the immunoreactivity of the antibody un...

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Autori principali: Milenic, Diane E, Wong, Karen J, Baidoo, Kwamena E, Nayak, Tapan K, Regino, Celeste AS, Garmestani, Kayhan, Brechbiel, Martin W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958576/
https://ncbi.nlm.nih.gov/pubmed/20716957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.2.5.13054
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