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Preparation, biological evaluation and pharmacokinetics of human anti-HER1 monoclonal antibody, Panitumumab, labeled with (86)Y for quantitative PET imaging of carcinoma
PURPOSE: Panitumumab, a human monoclonal antibody (mAb) that binds to the epidermal growth factor receptor (EGFR/HER1), was approved by the FDA in 2006 for the treatment of patients with HER1-expressing carcinoma. In this report, we describe preclinical development of (86)Y-CHX-A″-DTPA-panitumumab f...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892806/ https://ncbi.nlm.nih.gov/pubmed/20484421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.109.071290 |
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