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Intratumoral Heterogeneity of HER-2 Gene Amplification and Protein Overexpression in Breast Cancer

We report a case of a patient with invasive breast carcinoma which demonstrated HER-2 gene amplification on core biopsy, who relapsed while on adjuvant Trastuzumab therapy following her mastectomy and ultimately died 15 months after diagnosis. Surprisingly, analysis of multiple metastases harvested...

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Hlavní autoři: Wu, Julie M., Halushka, Marc K., Argani, Pedram
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958099/
https://ncbi.nlm.nih.gov/pubmed/20338615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2009.10.022
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