Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

Mammalian target of rapamycin (mTOR) is an important mediator of phosphoinositol-3-kinase (PI3K) signaling. PI3K signaling regulates B cell development, homeostasis and immune responses. However, the function and molecular mechanism of mTOR mediated PI3K signaling in B cells has not been fully eluci...

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Hlavní autoři: Lazorchak, Adam S, Liu, Dou, Facchinetti, Valeria, Di Lorenzo, Annarita, Sessa, William C, Schatz, David G, Su, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957800/
https://ncbi.nlm.nih.gov/pubmed/20705244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.031
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