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Efficient Serotype-Dependent Release of Functional Vector into the Culture Medium During Adeno-Associated Virus Manufacturing

Vectors based on adeno-associated virus (AAV) are the subject of increasing interest as research tools and agents for in vivo gene therapy. A current limitation on the technology is the versatile and scalable manufacturing of vector. On the basis of experience with AAV2-based vectors, which remain s...

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Main Authors: Vandenberghe, Luk H., Xiao, Ru, Lock, Martin, Lin, Jianping, Korn, Michael, Wilson, James M.
格式: Artigo
語言:Inglês
出版: Mary Ann Liebert, Inc. 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957237/
https://ncbi.nlm.nih.gov/pubmed/20649475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.107
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