Conformation-dependent high-affinity mAbs to prion proteins

Prion diseases are fatal, neurodegenerative illnesses caused by the accumulation of PrP(Sc), an aberrantly folded isoform of the normal, cellular prion protein (PrP(C)). Detection of PrP(Sc) commonly relies on immunochemical methods, a strategy hampered by the lack of antibodies specific for this di...

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Bibliografiske detaljer
Main Authors: Stanker, Larry H., Serban, Ana V., Cleveland, Elisa, Hnasko, Robert, Lemus, Azucena, Safar, Jiri, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957185/
https://ncbi.nlm.nih.gov/pubmed/20530267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902930
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