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Conformation-dependent high-affinity mAbs to prion proteins

Prion diseases are fatal, neurodegenerative illnesses caused by the accumulation of PrP(Sc), an aberrantly folded isoform of the normal, cellular prion protein (PrP(C)). Detection of PrP(Sc) commonly relies on immunochemical methods, a strategy hampered by the lack of antibodies specific for this di...

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Detalhes bibliográficos
Main Authors: Stanker, Larry H., Serban, Ana V., Cleveland, Elisa, Hnasko, Robert, Lemus, Azucena, Safar, Jiri, DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957185/
https://ncbi.nlm.nih.gov/pubmed/20530267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902930
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