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An efficient and versatile synthesis of GlcNAcstatins—potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold

We report a novel approach to the synthesis of GlcNAcstatins—members of an emerging family of potent and selective inhibitors of peptidyl O-GlcNAc hydrolase build upon tetrahydroimidazo[1,2-a]pyridine scaffold. Making use of a streamlined synthetic sequence featuring de novo synthesis of imidazoles...

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Main Authors: Borodkin, Vladimir S., van Aalten, Daan M.F.
Format: Artigo
Jezik:Inglês
Izdano: Pergamon Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956484/
https://ncbi.nlm.nih.gov/pubmed/20976183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2010.07.037
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