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Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

Cystic fibrosis transmembrane conductance regulator (CFTR) generates cAMP-regulated Cl- channels; mutations in CFTR cause defective Cl- channel function in cystic fibrosis epithelia. We used the patch-clamp technique to determine the single channel properties of Cl- channels in cell expressing recom...

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Published in:J Clin Invest
Main Authors: Berger, H A, Anderson, M P, Gregory, R J, Thompson, S, Howard, P W, Maurer, R A, Mulligan, R, Smith, A E, Welsh, M J
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1991
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295615/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1717515/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115450
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