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Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase
Hepatitis C virus (HCV) NS5B polymerase is a key target for the development of therapeutic agents aimed at the treatment of HCV infections. Here we report on the identification of novel allosteric inhibitors of HCV NS5B through a combination of structure-based virtual screening, synthesis and struct...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956004/ https://ncbi.nlm.nih.gov/pubmed/20627595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.05.030 |
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