Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase

Hepatitis C virus (HCV) NS5B polymerase is a key target for the development of therapeutic agents aimed at the treatment of HCV infections. Here we report on the identification of novel allosteric inhibitors of HCV NS5B through a combination of structure-based virtual screening, synthesis and struct...

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Detalhes bibliográficos
Main Authors: Talele, Tanaji T., Arora, Payal, Kulkarni, Shridhar S., Patel, Maulik R., Singh, Satyakam, Chudayeu, Maksim, Kaushik-Basu, Neerja
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956004/
https://ncbi.nlm.nih.gov/pubmed/20627595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.05.030
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