Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors

The hepatitis C virus (HCV) NS5B is essential for viral RNA replication and is therefore a prime target for development of HCV replication inhibitors. Here, we report the identification of a new class of HCV NS5B inhibitors belonging to the coumestan family of phytoestrogens. Based on the in vitro N...

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Bibliografiske detaljer
Main Authors: Kaushik-Basu, Neerja, Bopda-Waffo, Alain, Talele, Tanaji T., Basu, Amartya, Costa, Paulo R. R., da Silva, Alcides J. M., Sarafianos, Stefan G., Noël, François
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275130/
https://ncbi.nlm.nih.gov/pubmed/18203743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1178
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