Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase

Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Herein, we report the synthesis and in vitro evaluation of anti-NS5B polymerase activity of a molecular hybrid of our previously reported lead compounds 1 (IC(50) = 7.7 µM) and 2 (IC(50) = 10.6 µM) as repr...

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Detalhes bibliográficos
Main Authors: Patel, Bhargav, Krishnan, Ramalingam, Khadtare, Nikhil, Gurukumar, K. R., Basu, Amartya, Arora, Payal, Bhatt, Aaditya, Patel, Maulik R., Dana, Dibyendu, Kumar, Sanjai, Kaushik-Basu, Neerja, Talele, Tanaji T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651775/
https://ncbi.nlm.nih.gov/pubmed/23598249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.03.041
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