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Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition
Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Here we report the synthesis and biological evaluation of a new series of α,γ-diketo acids (DKAs) as NS5B polymerase inhibitors. We initiated structure-activity relationship (SAR) optimization around the f...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3208381/ https://ncbi.nlm.nih.gov/pubmed/21893371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.08.028 |
| Etiketak: |
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