The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase(2)

Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eukaryotic initiation factor 2 (eIF2) by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows cells time to reprogram stress-related gene express...

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Bibliographische Detailangaben
Hauptverfasser: Bunpo, Piyawan, Cundiff, Judy K., Reinert, Rachel B., Wek, Ronald C., Aldrich, Carla J., Anthony, Tracy G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Nutrition 2010
Schlagworte:
Nutritional Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955878/
https://ncbi.nlm.nih.gov/pubmed/20861212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.110.129197
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