The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase(2)

Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eukaryotic initiation factor 2 (eIF2) by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows cells time to reprogram stress-related gene express...

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Detalhes bibliográficos
Main Authors: Bunpo, Piyawan, Cundiff, Judy K., Reinert, Rachel B., Wek, Ronald C., Aldrich, Carla J., Anthony, Tracy G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Nutrition 2010
Assuntos:
Nutritional Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955878/
https://ncbi.nlm.nih.gov/pubmed/20861212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.110.129197
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